Denver Broncos (6-2) visit the Carolina Panthers (3-4) on Sunday at 1 p.m. ET from Bank of America Stadium in Charlotte. The Broncos lead the AFC West and are on a four-game winning streak, including a 28-24 victory over the Kansas City Chiefs on Nov. 1. The Panthers lead the NFC South but have lost two straight, most recently a 27-19 defeat to the Green Bay Packers on Oct. 29.
Denver is 3-1 against NFC opponents and 2-2 on the road. Carolina is 0-1 against AFC teams and 1-2 at home. Broncos safety Talanoa Hufanga (ankle) is a game-time decision.
The latest odds list Denver as a 2.5-point favorite with an over/under of 44.5 points. The Broncos are 6-2 against the spread this season, while the Panthers are 3-4. The money line has Denver at -142 and Carolina at +127.
A proven simulation model that has returned over $5,000 for $100 players on top-rated NFL picks since 2024 projects the over 44.5 points as the best value. The over has hit in four of the past seven head-to-head matchups, including three of the last four, and in each of Denver's last two games. The model also indicates one side of the spread hits in over 60% of simulations.
Quarterback Bo Nix leads Denver with 1,493 passing yards and nine touchdowns in eight starts, with Jaylen Waddle as his top target (29 receptions, 315 yards, two touchdowns). For Carolina, quarterback Bryce Young has thrown for 1,921 yards and 13 touchdowns, while running back Chuba Hubbard has rushed 118 times for 540 yards and five touchdowns. The Panthers rank ninth in the NFL in scoring at 25.4 points per game.
