Buffalo Bills and Minnesota Vikings, both 6-1 and leading their respective divisions, face off on Monday Night Football at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 8:15 p.m. ET.
The Bills enter after a 36-10 win over Baltimore on Nov. 1, while the Vikings suffered their first loss, 19-15 at Detroit the same day. Buffalo is 3-0 on the road this season; Minnesota is 3-0 at home.
Key injuries include Vikings quarterback Kyler Murray (hamstring) and receiver Jauan Jennings, while Bills receiver Joshua Palmer (hamstring) is out and headed to injured reserve.
Buffalo is a 3.5-point favorite with an over/under of 45.5 points. SportsLine's simulation model, which has returned over $5,000 for $100 players on top-rated NFL picks since inception, projects the Over 45.5 as the slight value side. The Over has hit in three of the last four Bills games and in three of the last four matchups in Minnesota.
The model also indicates one side of the spread hits in more than 50% of simulations. Carson Wentz is expected to start at quarterback for Minnesota, with three Vikings projected to exceed 60 scrimmage yards, while Josh Allen and James Cook are projected to combine for nearly 125 rushing yards.
