The Minnesota Vikings enter Week 8 as the NFL's last unbeaten team and face the Detroit Lions as 3-point underdogs on Sunday. Other notable matchups feature one-loss teams: the 5-1 Kansas City Chiefs visit the Denver Broncos (+1.5), and the Baltimore Ravens host the 5-1 Buffalo Bills (-3) with quarterback Lamar Jackson returning from an ankle injury that sidelined him for three games.
Model's Top Parlay Picks
SportsLine's computer model, which simulates each game 10,000 times, has produced five confident best bets for Week 8. A successful parlay of those picks would pay nearly 25-1. The model has gained more than $5,000 for $100 players on top-rated NFL picks since its inception and entered Week 8 on a 58-51 run on top-rated selections dating back to 2024.
Colts vs. Jaguars Over 46.5
The model backs the Over 46.5 points in the Indianapolis Colts vs. Jacksonville Jaguars game, a selection that hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, and Indianapolis games have gone Over in six of the last 10. Jacksonville ranks seventh in scoring at 25.7 points per game, while Indianapolis allows 25.7 points per game and recently traded defensive lineman DeForest Buckner.
Colts running back Jonathan Taylor has carried 140 times for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards, four touchdowns, and seven interceptions. For Jacksonville, Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, four interceptions, and a 106.3 passer rating in six starts. His top target, Parker Washington, has 26 receptions for 416 yards (16.0 average) and four touchdowns.
Additional Divisional Matchups
Week 8 also features several divisional games: Atlanta Falcons at Tampa Bay Buccaneers (-2.5), Cleveland Browns at Pittsburgh Steelers (-3.5), Indianapolis Colts at Jacksonville Jaguars (-10), New England Patriots at Miami Dolphins (+7), and Philadelphia Eagles at Washington Commanders (-6.5) on Sunday Night Football.
The model identifies four other matchups where it says the line is significantly off, including multiple spread picks that hit well over 50% of the time. Full details on the Week 8 NFL best bets and parlay are available via the model's platform.
