Syracuse Orange open as slim underdogs against the Clemson Tigers for their upcoming college football matchup, according to early betting lines.
The Orange are coming off a victory over the SMU Mustangs on October 31, 2026, at the JMA Wireless Dome, where tight end Noah Meyers scored the winning touchdown in the second half.
The game against Clemson will test Syracuse's resilience as they face a perennial powerhouse.
