No. 12 Ohio State (6-2, 4-1 Big Ten) hosts No. 23 Oregon (5-3, 3-2 Big Ten) at Ohio Stadium in Columbus on Saturday, with kickoff set for 3:30 p.m. ET on CBS and Paramount+.
The Buckeyes are 7.5-point favorites, and the over/under for total points is 44.5. The money line lists Ohio State at -294 and Oregon at +245.
Both teams will be without their starting quarterbacks: Ohio State's Julian Sayin is out with an arm injury, while Oregon's Dante Moore is sidelined with a concussion. Buckeyes receiver Brandon Inniss is listed as doubtful.
SportsLine's projection model, which simulates each game 10,000 times, leans toward the over on the 44.5-point total, hitting in 56% of simulations. The last four meetings between the programs have all surpassed 60 combined points, and the over has cashed in all four Ohio State home games this season as well as in two of three Oregon road games. Oregon's backup quarterback Dylan Raiola threw for 336 yards and three touchdowns last week, while Ohio State true freshman Luke Fahey posted 260 yards, one touchdown and zero turnovers at USC. The model projects over 500 combined passing yards for Saturday.
The model also indicates one side of the spread covers in more than 60% of simulations. SportsLine's model entered Week 10 with an 80-77 record on top-rated college football picks this season.
