The Minnesota Vikings, the NFL's last unbeaten team, enter Week 9 as 3-point home underdogs against the AFC East-leading Buffalo Bills on Monday Night Football. Meanwhile, the 6-1 San Francisco 49ers host the Las Vegas Raiders, who are 10-point underdogs.
The Arizona Cardinals face the Seattle Seahawks in an NFC West clash where the line has shifted significantly after news that quarterback Sam Darnold (quad) will not play. Gardner Minshew will start for Arizona, which rallied from 14 points down to defeat the Dallas Cowboys 33-30 in overtime in Week 8. Running back Tyler Allgeier leads the Cardinals' ground game with 72 carries for 323 yards and two touchdowns, including a 147-yard, one-score performance against Dallas. Tight end Trey McBride tops the receiving corps with 66 receptions for 544 yards and five touchdowns.
Seattle's offense, ranked 11th in scoring at 24.0 points per game, will turn to Drew Lock, who guided the team to 31 points in his previous start this season. Lock will have top target Jaxon Smith-Njigba (64 receptions, 985 yards, 9 touchdowns) at his disposal.
Other notable Week 9 matchups include the Los Angeles Rams vs. Washington Commanders (+4.5), Houston Texans vs. Los Angeles Chargers (+5.5), and Tampa Bay Buccaneers vs. Chicago Bears (-6) on Sunday Night Football. The Chargers have lost 10 consecutive games dating back to last season.
SportsLine's computer model, which simulates every NFL game 10,000 times, has generated five confident best bets for Week 9. The model entered the week on a 60-51 run on top-rated picks since 2024 and has returned more than $5,000 for $100 players on top-rated NFL selections since its inception. A successful parlay of the model's five picks would yield a payout of nearly +3000.
Among the highlighted selections, the model backs the Over 39.5 points in the Cardinals-Seahawks game, a side that hits in 76% of simulations. The Over has cashed in six of Arizona's last 10 games and three of Seattle's last five. Arizona averages 21.9 points per game (21st in the league), while Seattle averages 24.0 (11th).
The model also identifies four additional matchups where it believes the betting line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations. The complete Week 9 NFL best bets and parlay details are available exclusively through SportsLine.
