Week 10 college football odds feature seven matchups between teams in the initial College Football Playoff rankings, with several one-score lines across the SEC and a top showdown between No. 1 Miami and No. 11 Notre Dame.
In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss with a 3.5-point spread, and Texas faces Missouri at +2.5. Miami will be without injured star wide receiver Malachi Toney (ankle) when they visit Notre Dame, where the Fighting Irish are 7-point favorites seeking revenge for last year's loss.
The BYU-Utah rivalry, dating back over 100 years, sees Utah favored by 4.5 points at home. SportsLine's proven computer model, which simulates every FBS game 10,000 times and entered the week with an 80-77 record on top-rated picks, has locked in predictions for every matchup.
Among the model's top recommendations, Ohio State (-7.5, 45.5) is projected to cover against Oregon in a 3:30 p.m. ET kickoff on CBS and Paramount+. Freshman quarterback Luke Fahey is expected to perform better at home against an Oregon defense that has allowed more passing touchdowns than all but three Big Ten teams. The Buckeyes have covered 80% of home games since the start of 2025 and are projected to win by double digits, covering more than 60% of simulations.
Another highlighted pick is Oklahoma (+5.5, 45.5) covering at Florida. The Gators have lost three of four games, each by 19-plus points, and lead the SEC in penalty yards. Oklahoma quarterback John Mateer has averaged 296.5 total yards with four passing touchdowns and zero turnovers over his last two games, providing stability. The model also projects the Over to hit in 59% of simulations.
The model projects three upsets in ranked matchups according to the poll rankings. Full picks for every game are available at SportsLine.
Notable Week 10 Games (Saturday, Nov. 7)
BYU at Utah (-4.5, 49.5); Texas at Missouri (+2.5, 42.5); UCLA at Minnesota (+3.5, 38.5); Alabama at LSU (-6, 52.5); Oregon at Ohio State (-7.5, 45.5); Kentucky at Tennessee (-6, 49.5); Air Force at Army (-4, 43.5); Miami at Notre Dame (-7, 54.5); Michigan State at Michigan (-14, 39.5); Georgia at Ole Miss (+3.5, 56.5); Oklahoma at Florida (-5.5, 45.5).
