The Week 10 college football slate features several one-score lines among ranked opponents, particularly in the SEC where Alabama visits LSU as a 6.5-point underdog, Georgia travels to Ole Miss at +3.5, and Texas faces Missouri at +2.5. A top-5 showdown sees No. 1 Miami at No. 11 Notre Dame, with the Fighting Irish favored by 7.5 points while the Hurricanes will be without injured star wideout Malachi Toney. In a historic rivalry, BYU seeks a fourth straight win over Utah, with the Utes favored by 4.5 points at home.
Proven Model Projections
SportsLine's computer model, which simulates every FBS game 10,000 times and entered the week with an 80-77 record on top-rated picks, has locked in selections for every matchup. The model backs Ohio State (-7.5, 45.5) to cover against Oregon in a 3:30 p.m. ET kickoff on CBS and Paramount+, citing the Buckeyes' 80% cover rate at home since 2025 and a projected double-digit win. Another highlighted pick is Oklahoma (+6, 44.5) covering at Florida, with the model projecting the Over in 59% of simulations. The model also identifies three upsets in ranked matchups.
Notable Week 10 Games
Key games on Friday, Nov. 6 include Virginia Tech at SMU (-6.5), USF at East Carolina (-2.5), and TCU at Arizona (-7). Saturday, Nov. 7 features BYU at Utah (-4.5), Texas at Missouri (+2.5), Alabama at LSU (-6.5), Oregon at Ohio State (-7.5), Miami at Notre Dame (-7.5), Georgia at Ole Miss (+3.5), and Oklahoma at Florida (-6.5). Odds are subject to change.
