NFL Week 9 score predictions hinge on factors such as point differentials, recent trends, and rest advantages. One notable trend involves the Seattle Seahawks hosting the Arizona Cardinals on Sunday at 4:25 p.m. ET, where four of their last five meetings in Seattle have been decided by exactly 10 points. The Seahawks are 12.5-point favorites and have won 10 straight meetings against the Cardinals regardless of location.
Other games with spreads of at least a touchdown include Jaguars vs. Ravens (+10), Lions vs. Dolphins (+7), 49ers vs. Raiders (+10), and Chiefs vs. Jets (+10). SportsLine expert Eric Cohen, who finished the 2025-26 season with a 188-96-1 straight-up record (66%) and is 70-50-1 (58%) on his 2026 picks, has analyzed the latest odds and released his exact score predictions for all 15 games.
Cohen's top pick for Week 9 is the San Francisco 49ers (-10, 52.5) to defeat the Las Vegas Raiders while the Over also hits. The 49ers are coming off a bye week and are 8-1 straight-up following their last nine byes. The Raiders are 1-5 over their last six games with a rest disadvantage and rank 31st in scoring defense, while the 49ers rank sixth. Cohen notes that six straight Raiders games have seen 56 or more points and have hit the Over line.
Cohen projects a 34-24 final score in favor of the 49ers, highlighting quarterback Brock Purdy and running back Christian McCaffrey as key DFS options due to their rest. He also identifies five games projected to be decided by 13 or more points, which could offer significant value on alternate lines.
